Exonate plant den Beginn einer Phase-2b-Studie f\u00fcr seinen Wirkstoff EXN407, ein topisches SRPK1-Hemmer, zur Behandlung der nicht-proliferativen diabetischen Retinopathie (NPDR). Die CLEAR-DE-Studie soll Anfang 2026 starten. Die Studie wird die Wirksamkeit, Dosierung und Sicherheit von EXN407 an 140 Patienten mit NPDR in Australien, dem Nahen Osten und China untersuchen. Diese Entscheidung basiert auf positiven Ergebnissen einer Phase-1b\/2a-Studie im M\u00e4rz 2024. EXN407 zeigte gute Vertr\u00e4glichkeit und Sicherheit, ohne schwere Nebenwirkungen, und die Patienten hielten sich gut an die Behandlung. Erste Hinweise auf Wirksamkeit deuten auf eine Reduzierung von Gef\u00e4\u00dfleckagen hin, einem wichtigen Faktor f\u00fcr das Fortschreiten der diabetischen Retinopathie. Diabetische Retinopathie betrifft etwa ein Drittel der Diabetiker weltweit. Die fr\u00fche Form, NPDR, kann unbehandelt zu schweren Sehst\u00f6rungen f\u00fchren. Aktuell werden monatliche Injektionen in das Auge gegeben, oft erst bei fortgeschrittenen Symptomen. Dies verz\u00f6gert die Behandlung und kann zu bleibenden Sch\u00e4den f\u00fchren. EXN407 ist ein neuartiger Wirkstoff in Tropfenform, der zweimal t\u00e4glich angewendet wird und SRPK1 hemmt. Es beeinflusst die VEGF-Expression durch alternative RNA-Splei\u00dfung und bek\u00e4mpft so die Bildung abnormaler Blutgef\u00e4\u00dfe in der Netzhaut. Dr. Catherine Beech, CEO von Exonate, erkl\u00e4rte: \u201eDie Daten aus Phase 1b\/2a zeigen das gro\u00dfe Potenzial von EXN407 als nicht-invasive Behandlung f\u00fcr diabetische Augenerkrankungen.\u201c Sie f\u00fcgte hinzu: \u201eDiese Therapie k\u00f6nnte die Behandlung der fr\u00fchen Krankheitsstadien revolutionieren, indem sie den Patienten den Nutzen bietet, ohne auf Injektionen angewiesen zu sein. Das w\u00e4re ein gro\u00dfer Fortschritt f\u00fcr Patienten und \u00c4rzte. Wir freuen uns auf die Phase-2b-Studie und suchen strategische Partner f\u00fcr die Durchf\u00fchrung.\u201c<\/p>\n","protected":false},"excerpt":{"rendered":"
Exonate plant den Beginn einer Phase-2b-Studie f\u00fcr seinen Wirkstoff EXN407, ein topisches SRPK1-Hemmer, zur Behandlung der nicht-proliferativen diabetischen Retinopathie (NPDR). […]<\/p>\n","protected":false},"author":1,"featured_media":359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[448],"tags":[],"class_list":["post-358","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nachrichten"],"_links":{"self":[{"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/posts\/358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/comments?post=358"}],"version-history":[{"count":1,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/posts\/358\/revisions"}],"predecessor-version":[{"id":395,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/posts\/358\/revisions\/395"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/media\/359"}],"wp:attachment":[{"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/media?parent=358"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/categories?post=358"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hausarzt-dr-kahl.de\/apotheke\/wp-json\/wp\/v2\/tags?post=358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}